Sodium Sulfide Research Articles

PRECIPITATION OF ARSENIC FROM THERMAL WATER

The presented scientific research reveals the results of experiments on the precipitation of arsenic in the form of sulfide (As2S3) from the Daridag thermal water using sodium sulfide as a reagent. The main factors impacting the precipitation of the As2S3 compound were determined: the amount of precipitant (Na2S), the ratio of solid and liquid phases (S:L), pH of the initial solution, precipitation time and temperature, also optimal parameters were obtained. According to the results obtained, the yield during precipitation of arsenic tri-sulfide from from thermal water under certain temperature conditions (t=30-450С, pH=1-2; S:L - 1:1000; = 30-50 min.) were 99.6 %. The properties of the samples were studied by physicochemical research methods (X-Ray, SEM/EDS). X-ray phase analysis showed that the sediment sample obtained under these conditions is X-ray amorphous. The composition and morphology of the obtained sample was confirmed by scanning electron microscopy and spectroscopy (SEM/EDS)

Separation of V(Ⅴ) and Cr(Ⅵ) from vanadium-containing solutions based on E-pH diagrams of V-Cr-S-H2O system

The extremely similar physicochemical properties of vanadium and chromium lead to the difficulty in separating from each other. In this study, a novel hydrometallurgical process was devised to selectively precipitate chromium from vanadium-containing solutions, facilitating the efficient separation of V(V) and Cr(VI) while enabling the recovery of both vanadium and chromium species. The speciation of vanadium and chromium in solution was investigated through the construction of E-pH diagrams for V-Cr-S-H2O system at 298 K, 363 K, and 453 K. The results revealed that under conditions of pH approximately 12 and temperature 363 K, the reduction potential of SO42-/S2- was found to lie between that of CrO42-/Cr(OH)3 and VO43-/V2O3. This suggests that selective reduction of Cr(VI) could be achieved using S2- as reducing agent. In order to validate the theoretical findings, single-factor experiments were conducted on a laboratory scale. The effects of various parameters including initial pH, sodium sulfide dosage, reaction time, temperature, and initial concentration of vanadium-containing solutions on the chromium precipitation ratio and vanadium loss ratio were investigated. The experimental outcomes showed that the chromium precipitation ratio reached 99.8 % while the vanadium loss rate was only 3.5 % when the experiment was conducted at the optimal conditions: the initial pH was set to 12, sodium sulfide dosage was 2.0 times of the theoretical dosage, reaction time was 60 min and the temperature was 363 K. Then, the chromium concentration in the solution decreased from 2407 mg/L to 3.3 mg/L. Ultimately, V2O5 with a purity of 99.0 % and Cr2O3 with a purity of 97.2 % were successfully obtained.

H2SIncreases Blood Pressure via Activation of L-Type Calcium Channels with Mediation by HS•Generated from Reactions with Oxyhemoglobin.

Although the gasotransmitter hydrogen sulfide (H2S) is well known for its vasodilatory effects, H2S also exhibits vasoconstricting properties. Herein, it is demonstrated that administration of H2S as intravenous sodium sulfide (Na2S) increased blood pressure in sheep and rats, and this effect persisted after H2S has disappeared from the blood. Inhibition of the L-type calcium channel (LTCC) diminished the hypertensive effects. Incubation of Na2S with whole blood, red blood cells, methemoglobin, or oxyhemoglobin produced a hypertensive product of H2S, which is not hydrogen thioperoxide, metHb-SH- complexes, per-/poly- sulfides, or thiolsulfate, but rather a labile intermediate. One-electron oxidation of H2S by oxyhemoglobin generated its redox cousin, sulfhydryl radical (HS•). Consistent with the role of HS• as the hypertensive intermediate, scavenging HS• inhibited Na2S-induced vasoconstriction and activation of LTCCs. In conclusion, H2S causes vasoconstriction that is dependent on the activation of LTCCs and generation of HS• by oxyhemoglobin.

A corrosion failure analysis of a titanium tank used for production and storage of molten sodium sulfide

The corrosion failure of a titanium tank operating under high temperature of 220 °C for the production and storage of molten Na2S was thoroughly analyzed in this study. The various materialcharacterization methods, such as visual inspection, microscopic observation, chemical analysis, and mechanical assessment, demonstrated that hydride-inducedembrittlement plays a considerable role in the failure of the titanium tank. The key finding was that side products of H2, H2S, and Na2SO3 cause the destruction of the passive oxide film and, thus, provide the conditions for the absorption and penetration of atomic hydrogen, resulting in the formation of brittle TiH2 and subsequent flaking on the surface. To failure prevention of the titanium tank in such environments, the selection of tank material from Monel®400, blowing nitrogen gas into the system, and loading Na2CO3 into the reactive media were proposed. By complementary electrochemical investigations, it was clarified that Na2CO3 can stabilize the passive oxide film on the titanium surface and, therefore, enhance the resistance of the titanium tank against corrosion and failure. Notably, the present study can provide helpful references for enhancing the safety maintenance management of similar types of equipment.

H2 Reduction of Na2SO4 to Na2S Based on Dilute-Phase Fluidization

Sodium sulfate (Na2SO4) is used in the ecofriendly production of sodium sulfide (Na2S) through H2 reduction, thereby facilitating the valorization of Na2SO4. However, studies on this technique remain at the laboratory stage. This paper proposes a novel process involving the external circulation of Na2S in a dilute-phase fluidized system to address the low-temperature eutectic formation between Na2S and Na2SO4 during the H2 reduction of Na2SO4 to Na2S. The process aims to increase the reaction temperature of the Na2SO4 while reducing the volume of the liquid phase formed to prevent sintering blockages and enhance the reduction rate. In a proprietary experimental setup, the H2 reduction process in a dilute-phase fluidized system was investigated. The Na2S/Na2SO4 ratio and reaction temperature were determined to be critical factors influencing the Na2SO4 reduction rate. The melting point of the system increased and the amount of liquid phase produced decreased as the Na2S content was increased to more than 60%. The Na2S–Na2SO4 mixture (mass ratio of 80:20) existed as a solid at the reaction temperature of 740 °C. After roasting for 10 s, the Na2SO4 reduction rate reached 93.7% and the Na2S content in the mixture increased to 98.74%.

Removal of phosphoglycolate in hyperthermophilic archaea

Many organisms that utilize the Calvin-Benson-Bassham (CBB) cycle for autotrophic growth harbor metabolic pathways to remove and/or salvage 2-phosphoglycolate, the product of the oxygenase activity of ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco). It has been presumed that the occurrence of 2-phosphoglycolate salvage is linked to the CBB cycle, and in particular, the C2 pathway to the CBB cycle and oxygenic photosynthesis. Here, we examined 2-phosphoglycolate salvage in the hyperthermophilic archaeon Thermococcus kodakarensis, an obligate anaerobe that harbors a Rubisco that functions in the pentose bisphosphate pathway. T. kodakarensis harbors enzymes that have the potential to convert 2-phosphoglycolate to glycine and serine, and their genes were identified by biochemical and/or genetic analyses. 2-phosphoglycolate phosphatase activity increased 1.6-fold when cells were grown under microaerobic conditions compared to anaerobic conditions. Among two candidates, TK1734 encoded a phosphatase specific for 2-phosphoglycolate, and the enzyme was responsible for 80% of the 2-phosphoglycolate phosphatase activity in T. kodakarensis cells. The TK1734 disruption strain displayed growth impairment under microaerobic conditions, which was relieved upon addition of sodium sulfide. In addition, glycolate was detected in the medium when T. kodakarensis was grown under microaerobic conditions. The results suggest that T. kodakarensis removes 2-phosphoglycolate via a phosphatase reaction followed by secretion of glycolate to the medium. As the Rubisco in T. kodakarensis functions in the pentose bisphosphate pathway and not in the CBB cycle, mechanisms to remove 2-phosphoglycolate in this archaeon emerged independent of the CBB cycle.

The Effect of Sodium Sulfide and Anthracite Dosage on Selective Reduction of Limonite

The Effect of Sodium Sulfide and Anthracite Dosage on Selective Reduction of Limonite

Performance of Co9S8/Cu2S@LDH nanowires prepared by dual sulfur sources to promote oxygen evolution performance

Hydrogen production through water electrolysis is an effective method for obtaining clean energy. The oxygen evolution reaction plays a key role in the process of water electrolysis, and the development of efficient and stable oxygen evolution electrocatalysts is crucial to improve the efficiency of hydrogen production. This paper presents the preparation of Co9S8/Cu2S@LDH nanowire catalysts on copper foam using thiourea and sodium sulfide as dual sulfur sources by a hydrothermal method combined with electrochemical deposition. The composition, structure, and performance of the catalysts were investigated using characterization methods of XRD, SEM, Raman, and electrochemical analyses. Also, the mechanism of thiourea's role in the process of sulfurization of dual sulfur sources was also revealed. The results indicate that the introduction of thiourea facilitates the generation of the active center CoOOH and improves the catalytic efficiency of oxygen precipitation with a low overpotential of 199 mV at 10 mA/cm2 in 1.0 M KOH electrolyte. Additionally, the LDH deposited in the outer layer effectively prevents the oxidation of Co9S8/Cu2S and improves the catalyst's stability. Therefore, the prepared Co9S8/Cu2S@LDH nanowire catalyst exhibits high oxygen evolution reaction (OER) catalytic activity and stability in alkaline electrolyte, making it a promising OER catalyst.

Preparation of water-soluble cadmium sulfide quantum dots with narrow small-size distribution by controlling hydrodynamic cavitation device parameters

With the increasingly broad application of quantum dots in many fields, how to further improve the performance of quantum dots in various aspects has become an urgent problem to be solved. In this study, hydrodynamic cavitation (HC) technology was applied for the first time in the preparation of quantum dots. Specifically, cadmium sulfide quantum dots (CdS QDs) with small particle size, narrow distribution, high concentration and large Stokes shift are prepared. Firstly, CdS precipitation was obtained in an aqueous solvent, using cadmium nitrate tetrahydrate (Cd(NO3)2·4H2O) and sodium sulfide nonahydrate (Na2S·9H2O) as Cd and S sources, respectively. Subsequently, CdS QDs were formed from top to bottom through hydrodynamic cavitation reactor, which generates high temperature, high pressure, high-speed jets, shear forces, and shock waves. In summary, the intrinsic advantages of HC technology offer a new opportunity for manufacturing large-scale quantum dots with superb performance.

Investigation of Optical Characteristics and Synthesis of Cobalt-Doped Cds (Cds: Co) Using Simple and Rapid Microwave Activated Method

Cobalt-doped cadmium sulphide semiconductor nanoparticles (CdS: Co NPs) were made using a microwave-assisted method with different cobalt concentrations. Chemicals like sodium sulphide, cobalt chloride, and cadmium acetate were used. The Debye-Scherer equation helped find the nanoparticles' size, revealing a 2 to 4 nm range. X-ray diffraction showed a zinc-blend structure. The optical bandgap energies were found to be undoped and doped are 2.44eV and 2.58eV, respectively. For pure CdS, the XRD spectra display three main peaks at 2θ = 26.68°, 44.16°, and 52.32°. Modest alterations have been noted in 2θ for Co doping levels of 3% in CdS NPs. The peaks point to the samples' cubic structure and correlate to the (1 1 1), (2 2 0), and (3 1 1) planes. The sizes of the nanoparticles, which are 2.29 nm, 3.64 nm, for pure and Co (3%) doped CdS, were determined using the FWHM and Debye Scherer equation. The substitution of Co2+ion for Cd2+ion may be the cause of the decrease in nanoparticle size observed in the Co-doped CdS sample as concentration rises. The difference in the ionic radii of Cd2+ (0.98 Å) and Co2+ (0.72 Å) shows that when the concentration of Co-doped CdS increases, the lattice constant falls.  The peak at 3646 cm-1 in the higher energy area of the 400–4000 cm–1 FTIR spectra is attributed to the O–H stretching of absorbed water on the surface of CdS. Its bending vibration confirms the existence of water. Using HRTEM, the size of the produced nanoparticles was examined. Additionally, it confirms the sample's nanocrystalline structure. For 3% Co-doped CdS, the average size of randomly chosen nanoparticles is determined.

Screening of salt hydrates and cellulose nanocrystal composites for thermochemical energy storage using life cycle assessment

Salt hydrate systems via thermochemical reactions can provide thermal storage for renewable-sourced alternatives to traditional heating systems like natural gas. In this study, we use life cycle analysis (LCA) along with the material prices to screen salts based on environmental impact and cost. Additionally, we performed LCA of producing a composite material of salt and cellulose nanocrystals (CNC) at a weight ratio of four to one. CNC is a stabilizing agent for salt. We assessed the salt-CNC composites based on a laboratory scale and scaled-up processing to identify low environmental impact formulations and to identify high environmental impact processes in the composite production. In general, lanthanum chloride, lithium hydroxide, and lithium chloride should be avoided due to high environmental impact or cost. For pure salts, our results showed magnesium sulfate, zinc sulfate, and calcium chloride are typically preferred with a close second tier of magnesium and strontium chlorides and strontium bromide. For the composite material, magnesium sulfate was preferred followed by zinc sulfate, sodium sulfide, and strontium chloride. CNC has a significant environmental impact, contributing over 50% of the environmental impact for these composites. Therefore, CNC production with lower environmental impacts needs to be pursued. In composite production, the environmental impact of mixing and sonication can be reduced by scaling production. However, drying remains a high-impact process. These results can help guide salt selection for other salt-based thermochemical materials and further development of the salt-CNC composite.

Synthesis and assessment of novel Na2S dispersed high performance nanocomposite gel polymer electrolyte intended for sodium batteries and electric double layer capacitors

Sodium sulphide (Na2S) nanoparticles are synthesized by hydrothermal method and utilized for electrochemical application for the first time. A series of sodium-ion conducting nanocomposite gel polymer electrolytes (NCGPEs) incorporating poly (methyl methacrylate) i.e., (PMMA) as the polymer backbone, sodium tetrafluoro-borate (NaBF4) as the salt, tetraethylene glycol dimethyl ether (TEGDME) as the plasticizer, and Na2S as the active fillers, are fabricated and studied. The optimized electrolyte having PMMA/NaBF4/TEGDME matrix incorporated with 2.5 wt% Na2S nanoparticles exhibits a high ionic conductivity of 3.0 × 10−4 S cm−1, low activation energy of 0.13 eV and operating voltage range of ~2.8 V at ambient temperature. Thermal studies reveal that the fabricated NCGPEs have the ability to retain the gel phase up to 473 K. The X-ray diffraction (XRD) and Fourier transform Infra-red (FTIR) spectroscopy indicate changes in structure and the ion–filler–polymer interactions inside the synthesized NCGPEs. A proto-type sodium cell with an optimized NCGPE has an open circuit voltage of 2.3 V and a first discharge capacity of 205 mAh g−1. The electric double layer capacitor (EDLC) designed with optimized electrolyte has a specific capacitance of 58 F g−1 and is stable up to 2000 charge-discharge cycles.

Sulfur and nitrogen co-metabolism during composting: A role of sodium sulfide in regulating microbial communities and functional genes

Aerobic composting is an effective method for treating livestock and poultry manure. However, traditional aerobic composting often results in nitrogen loss and excessive N2O gas pollution in the atmosphere. In this study, metagenomics technology was used to investigate the co-metabolism of sulfur and nitrogen in composting with Na2S as an additive. The results showed that the content of nitrate and sulfate in the experimental group (T) was 19% and 34% higher, respectively, than that in the control group (CK) after composting maturation. The denitrification genes (narG, narH, nirK, and norB) and sulfur reduction gene (sat) in T were significantly inhibited, particularly on the fourth day. Actinobacteria and Proteobacteria were the dominant bacteria involved in sulfur and nitrogen co-metabolism. These findings indicated that the addition of Na2S effectively inhibits denitrification in composting, reducing N2O emissions and nitrogen loss, while increasing sulfate content and improving the quality of composting.

Effect of ammonium carbamate on catalytic sulfidation and flotation of azurite

This study aimed to investigate the effectiveness of catalytic sulfidation using ammonium carbamate and sodium sulfide to achieve satisfactory flotation recovery rates of azurite. The recovery rate of 82.51 % azurite was achieved through catalytic sulfidation. The Cu(II) and S2− species on the pure azurite surface were reduced and oxidized to Cu(I) species, Sn2− or S2− species, respectively. The analyses revealed that the rougher the azurite surface, the higher the atomic concentration of S and the more CuS2 species formed, and the more xanthate adsorption led to the formation of hydrophobic surfaces, promoting the flotation of azurite. The dissociative adsorption of H2O molecules on the (011) surface of azurite hindered further adsorption of HS− species on the (011) surface of azurite. The adsorption energy of HS− species on the (011) surface of azurite was more negative with NH3, indicating that the NH3 enhanced the adsorption of HS− species. In addition, the chemical bond strength of Cu-S formed through catalytic sulfidation of azurite was stronger than the chemical bond strength of Cu-S formed through direct sulfidation. The enhancement between S and Cu bonds greatly improved the stability of sulfide layers after catalytic sulfidation.

Neuromodulator hydrogen sulfide attenuates sickness behavior induced by lipopolysaccharide

Sickness behavior reflects a state of altered physiology and central nervous system function that occurs during systemic infection or inflammation, serving as an adaptive response to illness. This study aims to elucidate the role of hydrogen sulfide (H2S) in regulating sickness behavior and neuroinflammatory responses in a rat model of systemic inflammation. Adult male Wistar rats were treated with lipopolysaccharide (LPS) to induce sickness behavior. Intracerebroventricular (i.c.v.) pretreatments included aminooxyacetic acid (AOAA), an inhibitor of H2S synthesis, and sodium sulfide (NaHS), an H2S donor. Behavioral assays were conducted, along with the assessment of astrocyte activation, as indicated by GFAP expression in the hypothalamus. Pretreatment with NaHS mitigated LPS-induced behavioral changes, including hypophagia, social and exploratory deficits, without affecting peripheral cytokine levels, indicating a central modulatory effect. AOAA, conversely, accentuated certain behavioral responses, suggesting a complex role of endogenous H2S in sickness behavior. These findings were reinforced by a lack of effect on plasma interleukin levels but significant reduction in GFAP expression. Our findings support the central role of H2S in modulating neuroinflammation and sickness behavior, highlighting the therapeutic potential of targeting H2S signaling in neuroinflammatory conditions.

Impact of Reactive Sulfur Species on Entamoeba histolytica: Modulating Viability, Motility, and Biofilm Degradation Capacity.

Reactive sulfur species (RSS) like hydrogen sulfide (H2S) and cysteine persulfide (Cys-SSH) emerged as key signaling molecules with diverse physiological roles in the body, depending on their concentration and the cellular environment. While it is known that H2S and Cys-SSH are produced by both colonocytes and by the gut microbiota through sulfur metabolism, it remains unknown how these RSS affect amebiasis caused by Entamoeba histolytica, a parasitic protozoan that can be present in the human gastrointestinal tract. This study investigates H2S and Cys-SSH's impact on E. histolytica physiology and explores potential therapeutic implications. Exposing trophozoites to the H2S donor, sodium sulfide (Na2S), or to Cys-SSH led to rapid cytotoxicity. A proteomic analysis of Cys-SSH-challenged trophozoites resulted in the identification of >500 S-sulfurated proteins, which are involved in diverse cellular processes. Functional assessments revealed inhibited protein synthesis, altered cytoskeletal dynamics, and reduced motility in trophozoites treated with Cys-SSH. Notably, cysteine proteases (CPs) were significantly inhibited by S-sulfuration, affecting their bacterial biofilm degradation capacity. Immunofluorescence microscopy confirmed alterations in actin dynamics, corroborating the proteomic findings. Thus, our study reveals how RSS perturbs critical cellular functions in E. histolytica, potentially influencing its pathogenicity and interactions within the gut microbiota. Understanding these molecular mechanisms offers novel insights into amebiasis pathogenesis and unveils potential therapeutic avenues targeting RSS-mediated modifications in parasitic infections.

Oxidative stress resistance prompts pyrroloquinoline quinone biosynthesis in Hyphomicrobium denitrificans H4-45

Pyrroloquinoline quinone (PQQ) is a natural antioxidant with diverse applications in food and pharmaceutical industries. A lot of effort has been devoted toward the discovery of PQQ high-producing microbial species and characterization of biosynthesis, but it is still challenging to achieve a high PQQ yield. In this study, a combined strategy of random mutagenesis and adaptive laboratory evolution (ALE) with fermentation optimization was applied to improve PQQ production in Hyphomicrobium denitrificans H4-45. A mutant strain AE-9 was obtained after nearly 400 generations of UV-LiCl mutagenesis, followed by an ALE process, which was conducted with a consecutive increase of oxidative stress generated by kanamycin, sodium sulfide, and potassium tellurite. In the flask culture condition, the PQQ production in mutant strain AE-9 had an 80.4% increase, and the cell density increased by 14.9% when compared with that of the initial strain H4-45. Moreover, batch and fed-batch fermentation processes were optimized to further improve PQQ production by pH control strategy, methanol and H2O2 feed flow, and segmented fermentation process. Finally, the highest PQQ production and productivity of the mutant strain AE-9 reached 307 mg/L and 4.26 mg/L/h in a 3.7-L bioreactor, respectively. Whole genome sequencing analysis showed that genetic mutations in the ftfL gene and thiC gene might contribute to improving PQQ production by enhancing methanol consumption and cell growth in the AE-9 strain. Our study provided a systematic strategy to obtain a PQQ high-producing mutant strain and achieve high production of PQQ in fermentation. These practical methods could be applicable to improve the production of other antioxidant compounds with uncleared regulation mechanisms.Key points• Improvement of PQQ production by UV-LiCl mutagenesis combined with adaptive laboratory evolution (ALE) and fermentation optimization.• A consecutive increase of oxidative stress could be used as the antagonistic factor for ALE to enhance PQQ production.• Mutations in the ftfL gene and thiC gene indicated that PQQ production might be increased by enhancing methanol consumption and cell growth.

Sulfidization performance of hemimorphite surface in sodium sulfide system and identification of sulfidization products

The sulfidization performance and mechanism of hemimorphite surface in a sodium sulfide (Na2S) system were revealed, and surface sulfidization products were identified through various analytical methods. The results showed that Na2S concentration had a significant effect on the sulfidization of the hemimorphite surface. An increase in Na2S concentration could promote the interaction between S species in the pulp and mineral surfaces, thereby increasing the content of sulfidization products and hydrophobicity of hemimorphite surface. XPS and ToF-SIMS analyses showed that the sulfidization product was not the sole monosulfide on hemimorphite surfaces and it was composed of monosulfide (S2−) and polysulfide (Sn2−). The content of polysulfide on mineral surface increased with an increase in the Na2S concentration, which improves the activity of sulfidization products on hemimorphite surface.

Leather dye from Trema orientalis (L.) and its antibacterial effects

Synthetic leather dyes are chromatic agents specially formulated to impart color to leather substrates through dyeing. The current study involves the extraction of natural dye from the stem bark of Trema orientalis (L.) at different temperatures using water (with or without the addition of sodium hydroxide and sodium sulfide as additives). The optimal extraction was achieved at 80 °C without additives. Concentrating the extract using a rotary evaporator followed by freeze-drying resulted in a yield of 12.14%. The efficacy of the extracted dye was assessed by measuring the phenolic content, viscosity, and particle size. The highest value of total phenolic content of extract found, 266.13 mg GAE/g of dry extract, indicated the possibility of dyeing leather. The viscosity of the dye showed the temperature range of 51–54 ºC as optimum application criteria. The particle size of the dye exhibited a range spanning from 449 to 867 nanometers, indicating superb penetration ability through the leather pores. The antimicrobial efficacy was observed to be positive against a limited number of gram-positive as well as gram-negative bacteria. Final evaluation of the experimentally dyed sample against a control sample regarding relevant parameters viz. exhaustion, fastness, strength, SEM image indicated its potentiality as a colorant for leather industry.

Corin deficiency alleviates mucosal lesions in a mouse model of colitis induced by dextran sulfate sodium

AimsHigh dietary salt consumption is a risk factor for inflammatory bowel disease (IBD). Corin is a protease that activates atrial natriuretic peptide (ANP), thereby regulating sodium homeostasis. Corin acts in multiple tissues, including the intestine. In mice, corin deficiency impairs intestinal sodium excretion. This study aims to examine if reduced intestinal sodium excretion alters the pathophysiology of IBD. Main methodsWild-type (WT), Corin knockout (KO), and Corin kidney conditional KO (kcKO) mice were tested in a colitis model induced by dextran sulfide sodium (DSS). Effects of ANP on DSS-induced colitis were tested in WT and Corin KO mice. Body weight changes in the mice were monitored. Necropsy, histological analysis, and immunostaining studies were conducted to examine colon length and mucosal lesions. Fecal sodium levels were measured. RT-PCR was done to analyze proinflammatory genes in colon samples. Key findingsDSS-treated Corin KO mice had an ameliorated colitis phenotype with less body weight loss, longer colon lengths, smaller mucosal lesions, lower disease scores, more preserved goblet cells, and suppressed proinflammatory genes in the colon. In longitudinal studies, the DSS-treated Corin KO mice had delayed onset of colon mucosal lesions. ANP administration lessened the colitis in WT, but not Corin KO, mice. Analyses of WT, Corin KO, and Corin kcKO mice indicated that fecal sodium excretion, controlled by intestinal corin, may regulate inflammatory responses in DSS-induced colitis in mice. SignificanceOur findings indicate a role of corin in intestinal pathophysiology, suggesting that reduced intestinal sodium level may offer protective benefits against IBD.